Journal article
Elucidating the association between depression, anxiety, and cognition in middle-aged adults: Application of dimensional and categorical approaches
S Perin, J Lai, M Pase, L Bransby, R Buckley, N Yassi, RH Pietrzak, P Maruff, YY Lim
Journal of Affective Disorders | Published : 2022
Abstract
Background: In older adults, depressive and anxiety symptoms are associated with dementia risk, and represent a manifestation of the dementia prodrome. Understanding how these symptoms are related to cognition in midlife may inform risk models of dementia. Methods: This study examined the relationship between depressive and anxiety symptoms, and cognition, in a sample (n= 2,657) of participants enrolled in the Healthy Brain Project. Depressive and Anxiety symptoms were assessed using the Depression Anxiety and Stress Scale, Hospital Anxiety and Depression Scale, and centre for Epidemiological Studies Depression Scale. Objective cognition was assessed using the Cogstate Brief Battery and subj..
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Awarded by National Institutes of Health
Funding Acknowledgements
[ "The Healthy Brain Project (healthybrainproject.org.au) is funded by the National Health and Medical Research Council (GNT1158384, GNT1147465, GNT1111603, GNT1105576, GNT1104273, GNT1158384, GNT1171816), the Alzheimer's Association (AARG17-591424, AARG-18-591358, AARG-19-643133), the Dementia Australia Research Foundation, the Bethlehem Griffiths Research Foundation, the Yulgilbar Alzheimer's Research Program, the National Heart Foundation of Australia (102052), and the Charleston Conference for Alzheimer's Disease.", "L Bransby is supported by a Dementia Australia Research Foundation PhD Scholarship. MP Pase is supported by a Heart Foundation Future Leader Fellowship (GNT102052). RF Buckley is supported by a National Institutes of Health K99-R00 award (K99AG061238). YY Lim is supported by an NHMRC Career Development Fellowship (GNT1162645)." ]